CAT# : L2C02901
Product Name : Human Hsp90αA1 protein
Protein description Recombinant Human Hsp90αA1 protein with N terminal
Trx.tag and His tag.
Molecular weight 85 KD
Expression host: Escherichia coli
Purification notes Sepharose derived purification.
Biological activity Use as a Tumor marker or a promising target for anti-cancer drug development.
Storage instructions Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer 0.01M PBS, 0.15M NaCl, 2mM EDTA pH 7.4
Application ELISA ;WESTERN
Relevance HSP90 has been identified in the cytosol, nucleus and endoplasmic reticulum, and is reported to exist in many tissue types. In several tissues, including smooth muscle, HSP90 comprises up to 2% of total cellular protein. HSP90 functions as a dimer, assembled as part of heterocomplex. It possesses ATP-binding site and low ATPase activity. HSP90 is able to associate with actin filaments in certain conditions. Another important property of HSP90 is the binding of unoccupied steroid hormone receptors. HSP90 has been characterized as a molecular chaperone able to keep the target protein in a folding-competent state. It has an enhanced chaperone activity in oligomeric form at high temperatures. HSP90 function is sensitive to bivalent cations concentration.
For research use only.